TNRC6B and AGO4

Data Source:
BioGRID (proximity labelling technology, pull down)

		TNRC6B	AGO4
Description		trinucleotide repeat containing adaptor 6B	argonaute RISC component 4
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytosol	P-body Nucleus Cytoplasm Cytosol Membrane RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex
	Molecular Function	RNA Binding Protein Binding	Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding MiRNA Binding
	Biological Process	Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Silencing By RNA Post-transcriptional Gene Silencing By RNA Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MiRNA Mediated Inhibition Of Translation	MRNA Catabolic Process Synaptonemal Complex Assembly Male Meiotic Nuclear Division Wnt Signaling Pathway, Calcium Modulating Pathway Male Gonad Development RNA Secondary Structure Unwinding MiRNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Cell Morphogenesis Pre-miRNA Processing Post-transcriptional Gene Silencing By RNA Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation MRNA Cleavage Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Negative Regulation Of Apoptotic Process Regulation Of Megakaryocyte Differentiation MRNA Cleavage Involved In Gene Silencing By SiRNA
Pathways		Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Breast size ( 29855537) Chronotype ( 26955885 30696823) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31015462) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Hand grip strength ( 25637336) Height ( 19570815) Immature fraction of reticulocytes ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mammographic density (dense area) ( 25342443) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Meat-related diet ( 32066663) Morning person ( 30696823) Neutrophil percentage of white cells ( 27863252) Prostate cancer ( 23065704 19117981) Pulse pressure ( 27841878 27618447 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 27618447) Uterine fibroids ( 21460842 31488892 31249589 30194396 31649266) Uterine fibroids (MTAG) ( 31488892)
Interacting Genes		3 interacting genes: AGO4 PAN3 UBQLN4	4 interacting genes: APP TNRC6A TNRC6B TNRC6C
Entrez ID		23112	192670
HPRD ID		10021	09559
Ensembl ID		ENSG00000100354	ENSG00000134698
Uniprot IDs		A0A024R1N5 Q9UPQ9	Q9HCK5
PDB IDs			6OON
Enriched GO Terms of Interacting Partners?
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