NAALADL2 and GRM2

Data Source:
BioGRID (two hybrid)

		NAALADL2	GRM2
Description		N-acetylated alpha-linked acidic dipeptidase like 2	glutamate metabotropic receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Presynaptic Membrane Astrocyte Projection Integral Component Of Postsynaptic Membrane
	Molecular Function	Protein Binding	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding
	Biological Process	Response To Bacterium	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Protein Kinase B Signaling Regulation Of Synaptic Transmission, Glutamatergic Glutamate Homeostasis
Pathways			G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			LY2140023
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Autism spectrum disorder ( 26398136) Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Familial lung adenocarcinoma ( 29924316) Height ( 23456168) Idiopathic downbeat nystagmus ( 32157568) Influenza A (H1N1) severity ( 26379185) Kawasaki disease ( 19132087) Loneliness ( 27629369) Metabolite levels (MHPG) ( 23319000) Mitochondrial DNA copy number ( 30704525) Number of sexual partners ( 30643258) Priapism in sickle cell disease ( 31668730) Prostate cancer aggressiveness ( 25939597) Rapid automised naming of pictures ( 30741946) Response to alcohol consumption (flushing response) ( 29460428) Sleep duration ( 23728906) Systemic lupus erythematosus ( 21408207)
Interacting Genes		6 interacting genes: APP GPR25 GRM2 ITM2B LAPTM4B SLC30A3	29 interacting genes: ACBD5 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MFSD14B MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 STOM TAMALIN TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1
Entrez ID		254827	2912
HPRD ID		16388	04977
Ensembl ID		ENSG00000177694	ENSG00000164082
Uniprot IDs		Q58DX5	Q14416
PDB IDs			4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ
Enriched GO Terms of Interacting Partners?
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