ZNF620 and EIF4A2

Data Source:
BioGRID (two hybrid)

		ZNF620	EIF4A2
Description		zinc finger protein 620	eukaryotic translation initiation factor 4A2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Cytoplasmic Translational Initiation Translational Initiation Regulation Of Translational Initiation Viral Process Negative Regulation Of RNA-directed 5'-3' RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor
Pathways		Generic Transcription Pathway	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Neuroticism ( 29255261)
Interacting Genes		72 interacting genes: ABLIM3 ATG9A BFSP2 BOLA2 BOLA2B C1orf216 C22orf39 CABP5 CARD9 CCDC102B CCDC6 CCHCR1 CCNC CDCA7L CDKN2D CHAF1A CIB3 CINP CLIC3 CTNNA3 DGCR6L DTX2 EAF1 EEF2KMT EIF4A2 EPM2AIP1 EXOSC5 FHL2 GAS8 GLYCTK GRB2 GYS1 IGFN1 IL16 JRK KCTD9 LMO1 LMO3 MAGOHB MAP2K5 METTL21A MFAP1 MISP MLX MYOZ3 NDOR1 NME7 NOXA1 OAZ3 PIBF1 PIK3R3 PLOD3 POLE2 RIPPLY1 RUSC1 SAAL1 SART3 SLIT1 SNAPC3 TENT5B TPM2 TRAF4 TRIM10 TRIM50 TSEN15 TSR2 USP20 ZBTB16 ZFHX3 ZIC1 ZNF24 ZNF648	23 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620
Entrez ID		253639	1974
HPRD ID		15878	03062
Ensembl ID		ENSG00000177842	ENSG00000156976
Uniprot IDs		Q6ZNG0	Q14240
PDB IDs			3BOR
Enriched GO Terms of Interacting Partners?
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