ACKR1 and CXCL5

Data Source:
HPRD (in vivo)

		ACKR1	CXCL5
Description		atypical chemokine receptor 1 (Duffy blood group)	C-X-C motif chemokine ligand 5
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GO Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity C-C Chemokine Binding Signaling Receptor Activity	Protein Binding Chemokine Activity Identical Protein Binding CXCR Chemokine Receptor Binding
	Biological Process	Defense Response Inflammatory Response G Protein-coupled Receptor Signaling Pathway Regulation Of Chemokine Production Chemokine-mediated Signaling Pathway	Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide
Pathways		Peptide ligand-binding receptors	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Eotaxin levels ( 27989323) Growth-regulated protein alpha levels ( 27989323) Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Monocyte chemoattractant protein-1 levels ( 27989323 31217265) Neutrophil level response to clozapine in treatment-resistant schizophrenia ( 30647433)	CXCL5 levels ( 25147954) Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		9 interacting genes: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8 MTNR1B	20 interacting genes: ACKR1 ACTN3 ALPP CCL11 CCL20 CXCL1 CXCL14 CXCL2 CXCL3 CXCR1 CXCR2 EFEMP2 FBLN1 GRN MEOX2 MGAT5B MMP9 NOTCH2NLA VWC2L XCL2
Entrez ID		2532	6374
HPRD ID		00192	08976
Ensembl ID		ENSG00000213088	ENSG00000163735
Uniprot IDs		Q16570 Q5Y7A1 Q5Y7A2	P42830 Q6I9S7
PDB IDs		4NUU 4NUV	2MGS
Enriched GO Terms of Interacting Partners?
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