ACKR1 and CCL7

Data Source:
HPRD (in vivo)

		ACKR1	CCL7
Description		atypical chemokine receptor 1 (Duffy blood group)	C-C motif chemokine ligand 7
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GO Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Membrane Recycling Endosome	Extracellular Space
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity C-C Chemokine Binding Signaling Receptor Activity	Protein Binding Chemokine Activity Heparin Binding CCR1 Chemokine Receptor Binding CCR2 Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Defense Response Inflammatory Response G Protein-coupled Receptor Signaling Pathway Regulation Of Chemokine Production Chemokine-mediated Signaling Pathway	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Response To Gamma Radiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Eosinophil Chemotaxis Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Ethanol Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Peptide ligand-binding receptors	Chemokine receptors bind chemokines
Drugs
Diseases
GWAS		Eotaxin levels ( 27989323) Growth-regulated protein alpha levels ( 27989323) Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Monocyte chemoattractant protein-1 levels ( 27989323 31217265) Neutrophil level response to clozapine in treatment-resistant schizophrenia ( 30647433)	Blood protein levels ( 30072576 29875488) Crohn's disease ( 28067908 22412388 21102463) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908)
Interacting Genes		9 interacting genes: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8 MTNR1B	18 interacting genes: ACKR1 ACKR2 ACKR4 CCR1 CCR10 CCR3 CCR5 CXCL6 FEZ1 MMP1 MMP13 MMP14 MMP2 MMP3 TLE5 UBQLN1 UBQLN2 XCL2
Entrez ID		2532	6354
HPRD ID		00192	01150
Ensembl ID		ENSG00000213088	ENSG00000108688
Uniprot IDs		Q16570 Q5Y7A1 Q5Y7A2	P80098
PDB IDs		4NUU 4NUV	1BO0 1NCV 4ZKC
Enriched GO Terms of Interacting Partners?
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