ACKR1 and CCL17

Data Source:
HPRD (in vivo)

		ACKR1	CCL17
Description		atypical chemokine receptor 1 (Duffy blood group)	C-C motif chemokine ligand 17
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GO Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Membrane Recycling Endosome	Extracellular Space
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity C-C Chemokine Binding Signaling Receptor Activity	Signaling Receptor Binding Protein Binding Chemokine Activity CCR4 Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Defense Response Inflammatory Response G Protein-coupled Receptor Signaling Pathway Regulation Of Chemokine Production Chemokine-mediated Signaling Pathway	Monocyte Chemotaxis Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organism Development Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation Of Myoblast Differentiation Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Peptide ligand-binding receptors	Chemokine receptors bind chemokines
Drugs
Diseases
GWAS		Eotaxin levels ( 27989323) Growth-regulated protein alpha levels ( 27989323) Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Monocyte chemoattractant protein-1 levels ( 27989323 31217265) Neutrophil level response to clozapine in treatment-resistant schizophrenia ( 30647433)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		9 interacting genes: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8 MTNR1B	9 interacting genes: ACKR1 CCL21 CCL25 CCL26 CCL28 CCL5 CCR4 CCR8 VCAM1
Entrez ID		2532	6361
HPRD ID		00192	03309
Ensembl ID		ENSG00000213088	ENSG00000102970
Uniprot IDs		Q16570 Q5Y7A1 Q5Y7A2	Q92583
PDB IDs		4NUU 4NUV	1NR2 1NR4 5WK3
Enriched GO Terms of Interacting Partners?
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