RUSC1 and NTRK1

Data Source:
HPRD (two hybrid, in vivo)

		RUSC1	NTRK1
Description		RUN and SH3 domain containing 1	neurotrophic receptor tyrosine kinase 1
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GO Annotations	Cellular Component	Nucleus Early Endosome Golgi Apparatus Cytosol Microtubule Postsynaptic Density Microtubule Cytoskeleton Cytoplasmic Vesicle	Golgi Membrane Early Endosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Neuronal Cell Body Receptor Complex Recycling Endosome Membrane
	Molecular Function	Actin Binding Protein Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Neurotrophin P75 Receptor Binding Protein Binding ATP Binding Nerve Growth Factor Receptor Activity Kinase Binding Identical Protein Binding Protein Homodimerization Activity Neurotrophin Binding Nerve Growth Factor Binding
	Biological Process	Protein Polyubiquitination	Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Aging Learning Or Memory Circadian Rhythm Negative Regulation Of Cell Population Proliferation Response To Radiation Programmed Cell Death Involved In Cell Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Olfactory Nerve Development B Cell Differentiation Response To Nutrient Levels Positive Regulation Of Kinase Activity Peptidyl-tyrosine Autophosphorylation Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Sympathetic Nervous System Development Response To Axon Injury Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrostatic Pressure Response To Electrical Stimulus Regulation Of Protein Kinase B Signaling Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Sertoli Cell Development Axonogenesis Involved In Innervation Behavioral Response To Formalin Induced Pain Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Nicotine Cellular Response To Amyloid-beta Cellular Response To Nerve Growth Factor Stimulus
Pathways			PLC-gamma1 signalling Signalling to RAS ARMS-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling Retrograde neurotrophin signalling NGF-independant TRKA activation TRKA activation by NGF TRKA activation by NGF Signalling to p38 via RIT and RIN PI3K/AKT activation PI3K/AKT activation Signalling to STAT3
Drugs			Amitriptyline Imatinib Regorafenib Entrectinib Fostamatinib Cenegermin Larotrectinib Pralsetinib
Diseases			Neuroblastoma Thyroid cancer
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Red cell distribution width ( 32888494)
Interacting Genes		92 interacting genes: ABHD11 ABHD5 ABI2 AKAP8L ANKS1A APP ATP6V0D2 BPIFA1 C1orf109 CCDC120 CCDC57 CCHCR1 CCNC CDKN2B CMTM6 CREM CRYBA2 CTAG1A CTAG1B DMRT3 DOK6 DTX2 DVL2 EXOC8 EXOSC8 FAM9B FNDC3B GCM2 HMG20A HNRNPF INSC KCTD9 KRTAP19-1 KRTAP19-5 KRTAP6-2 KRTAP8-1 LIMS3 LIMS4 LMO2 MAGEA3 MAGEA6 MAGED1 MED25 MEIS2 MISP MOAP1 MORN3 MYOZ3 N4BP3 NICN1 NTAQ1 NTRK1 NUDT22 OIP5 P4HA3 PFDN5 PIK3R3 PLA2G6 PM20D2 PNMA1 POLR1C PRDM14 PRR35 RBPMS SMARCB1 SMYD1 SOHLH1 SPAG8 STUB1 SUOX TBC1D25 TCHP TEKT4 TENT5B TLE5 TRAPPC6A TRIM55 TRIM63 TRIM73 TSSK3 TTC19 TTC7B UFSP1 VGLL3 WWOX WWP2 ZIC1 ZMYND12 ZNF34 ZNF620 ZNF765 ZNF77	40 interacting genes: ABL1 ARHGAP32 CAV1 CRK DNAJA3 DYNLL1 ERBB2 FRS2 FRS3 GIPC1 GRB2 IRS1 IRS2 KIDINS220 MAPK3 MATK NEDD4L NGF NGFR NTF3 PIK3R1 PLCG1 PTPN1 PTPN11 PTPRR RAP1A RASA1 RASGRF1 RUSC1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SORT1 SQSTM1 TPTE TRAF4 TRAF6 UBB
Entrez ID		23623	4914
HPRD ID		10206	01869
Ensembl ID		ENSG00000160753	ENSG00000198400
Uniprot IDs		B4DQB8 Q9BVN2	P04629 X5DR71
PDB IDs		4GIW	1HE7 1SHC 1WWA 1WWW 2IFG 2N90 4AOJ 4CRP 4F0I 4GT5 4PMM 4PMP 4PMS 4PMT 4YNE 4YPS 5H3Q 5I8A 5JFS 5JFV 5JFW 5JFX 5KMI 5KMJ 5KMK 5KML 5KMM 5KMN 5KMO 5KVT 5WR7 6D1Y 6D1Z 6D20 6D22 6DKB 6DKG 6DKI 6DKW 6IQN 6J5L 6NPT 6NSP 6NSS 6PL1 6PL2 6PL3 6PL4 6PMA 6PMB 6PMC 6PME
Enriched GO Terms of Interacting Partners?
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