TSSK2 and TSEN15

Data Source:
BioGRID (two hybrid)

		TSSK2	TSEN15
Description		testis specific serine kinase 2	tRNA splicing endonuclease subunit 15
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Centriole	Nucleoplasm Nucleolus
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein-containing Complex Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Nucleic Acid Binding Nuclease Activity Protein Binding
	Biological Process	Protein Phosphorylation Multicellular Organism Development Spermatid Development Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways			tRNA processing in the nucleus
Drugs
Diseases
GWAS		Platelet aggregation ( 29185836)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronotype ( 30696823) Height ( 20881960) Hip circumference adjusted for BMI ( 25673412) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Type 2 diabetes ( 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412)
Interacting Genes		8 interacting genes: APP FAM229B LZTS2 PTPRD SKIV2L TFG TSEN15 TSKS	34 interacting genes: AIF1L ARID5A ASB12 CCDC33 DDIT4L DNAAF6 ENKD1 ERBB2 EXOSC4 GORASP2 HSF2BP IKZF3 INCA1 LMO2 LMO4 LRIF1 MEI4 MIPOL1 NBPF3 PBX4 PHOSPHO2 PLB1 POLR2G POU6F2 REL TASOR2 TEPSIN TLE5 TSEN34 TSSK2 USP54 ZMAT2 ZNF554 ZNF620
Entrez ID		23617	116461
HPRD ID		10255	12292
Ensembl ID		ENSG00000206203	ENSG00000198860
Uniprot IDs		A0ZT99 Q96PF2	A0A2U3TZM3 B1ALV0 E9PPN1 Q8WW01
PDB IDs			2GW6
Enriched GO Terms of Interacting Partners?
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