TSEN15 and ZMAT2

Data Source:
BioGRID (two hybrid)

		TSEN15	ZMAT2
Description		tRNA splicing endonuclease subunit 15	zinc finger matrin-type 2
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Nucleus U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome
	Molecular Function	Nucleic Acid Binding Nuclease Activity Protein Binding	DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing Nucleic Acid Phosphodiester Bond Hydrolysis	MRNA Splicing, Via Spliceosome
Pathways		tRNA processing in the nucleus
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronotype ( 30696823) Height ( 20881960) Hip circumference adjusted for BMI ( 25673412) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Type 2 diabetes ( 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412)	Major depressive disorder ( 27479909) Refractive error ( 32231278) Schizophrenia ( 28991256 29483656) Serum immune biomarker levels ( 32066700) Systolic blood pressure ( 30224653)
Interacting Genes		34 interacting genes: AIF1L ARID5A ASB12 CCDC33 DDIT4L DNAAF6 ENKD1 ERBB2 EXOSC4 GORASP2 HSF2BP IKZF3 INCA1 LMO2 LMO4 LRIF1 MEI4 MIPOL1 NBPF3 PBX4 PHOSPHO2 PLB1 POLR2G POU6F2 REL TASOR2 TEPSIN TLE5 TSEN34 TSSK2 USP54 ZMAT2 ZNF554 ZNF620	40 interacting genes: AK8 AMH BICD2 CALCOCO1 CBY2 CCDC57 CDR2 CEP76 ERBB2 FSD2 FXR1 FXR2 GOLGA2 GOLGA6L9 GRIPAP1 HAP1 HMBOX1 IKZF1 KANK2 KRT40 LZTS2 MEOX2 MTUS2 NAB2 NUTF2 PHC2 PICK1 PRPH SPAG5 SSX2IP TFEC TFIP11 TNIP1 TRAF2 TRIM36 TRIM37 TSEN15 VPS52 ZBTB14 ZBTB8A
Entrez ID		116461	153527
HPRD ID		12292	08094
Ensembl ID		ENSG00000198860	ENSG00000146007
Uniprot IDs		A0A2U3TZM3 B1ALV0 E9PPN1 Q8WW01	Q96NC0
PDB IDs		2GW6	5O9Z 6AHD
Enriched GO Terms of Interacting Partners?
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