TSEN15 and ZNF554

Data Source:
BioGRID (two hybrid)

		TSEN15	ZNF554
Description		tRNA splicing endonuclease subunit 15	zinc finger protein 554
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Nucleoplasm Nucleolus
	Molecular Function	Nucleic Acid Binding Nuclease Activity Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing Nucleic Acid Phosphodiester Bond Hydrolysis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		tRNA processing in the nucleus	Generic Transcription Pathway
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronotype ( 30696823) Height ( 20881960) Hip circumference adjusted for BMI ( 25673412) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Type 2 diabetes ( 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412)
Interacting Genes		34 interacting genes: AIF1L ARID5A ASB12 CCDC33 DDIT4L DNAAF6 ENKD1 ERBB2 EXOSC4 GORASP2 HSF2BP IKZF3 INCA1 LMO2 LMO4 LRIF1 MEI4 MIPOL1 NBPF3 PBX4 PHOSPHO2 PLB1 POLR2G POU6F2 REL TASOR2 TEPSIN TLE5 TSEN34 TSSK2 USP54 ZMAT2 ZNF554 ZNF620	2 interacting genes: POLR1C TSEN15
Entrez ID		116461	115196
HPRD ID		12292	15837
Ensembl ID		ENSG00000198860	ENSG00000172006
Uniprot IDs		A0A2U3TZM3 B1ALV0 E9PPN1 Q8WW01	B3KNM4 Q86TJ5
PDB IDs		2GW6
Enriched GO Terms of Interacting Partners?
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