SIRT1 and BHLHE41

Data Source:
BioGRID (pull down)

		SIRT1	BHLHE41
Description		sirtuin 1	basic helix-loop-helix family member e41
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Heterochromatin Fibrillar Center Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Chromatin Silencing Complex Nucleolus Cytoplasm Mitochondrion Cytosol PML Body RDNA Heterochromatin ESC/E(Z) Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity Enzyme Binding Protein Deacetylase Activity NAD-dependent Protein Deacetylase Activity Nuclear Hormone Receptor Binding Histone Binding Identical Protein Binding HLH Domain Binding BHLH Transcription Factor Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) Mitogen-activated Protein Kinase Binding NAD+ Binding Protein-propionyllysine Depropionylase Activity Keratin Filament Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Single Strand Break Repair Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Assembly Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Synthesis Involved In DNA Repair Angiogenesis Ovulation From Ovarian Follicle Cellular Glucose Homeostasis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Adaptive Immune Response Chromatin Organization DNA Methylation-dependent Heterochromatin Assembly Protein ADP-ribosylation Protein Deacetylation Triglyceride Mobilization Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Regulation Of Mitotic Cell Cycle Muscle Organ Development Cell Aging Positive Regulation Of Cell Population Proliferation Cellular Response To Starvation Negative Regulation Of Gene Expression Regulation Of Centrosome Duplication Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Regulation Of Glucose Metabolic Process Macrophage Cytokine Production Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Positive Regulation Of Macroautophagy Protein Ubiquitination Histone Deacetylation Peptidyl-lysine Acetylation Macrophage Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Prostaglandin Biosynthetic Process Heterochromatin Assembly Protein Destabilization Negative Regulation Of TOR Signaling Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Insulin Circadian Regulation Of Gene Expression Leptin-mediated Signaling Pathway Regulation Of Smooth Muscle Cell Apoptotic Process Peptidyl-lysine Deacetylation Cellular Triglyceride Homeostasis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Phosphorylation Response To Hydrogen Peroxide Behavioral Response To Starvation Cholesterol Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Leptin Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA Repair Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway White Fat Cell Differentiation Negative Regulation Of Helicase Activity Positive Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Modification Cellular Response To Hydrogen Peroxide Heterochromatin Maintenance Regulation Of Bile Acid Biosynthetic Process UV-damage Excision Repair Histone H3 Deacetylation Cellular Response To Tumor Necrosis Factor Negative Regulation Of Histone H3-K14 Acetylation Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Brown Fat Cell Differentiation Stress-induced Premature Senescence Protein Depropionylation Regulation Of Cellular Response To Heat Negative Regulation Of Histone H3-K9 Trimethylation Negative Regulation Of Neuron Death Negative Regulation Of Protein Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Adipose Tissue Development Histone H3-K9 Deacetylation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Macrophage Apoptotic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Cellular Response To Testosterone Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Negative Regulation Of Myotube Differentiation Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis
Pathways		Regulation of HSF1-mediated heat shock response Circadian Clock SIRT1 negatively regulates rRNA expression SIRT1 negatively regulates rRNA expression Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation	BMAL1:CLOCK,NPAS2 activates circadian gene expression Circadian Clock
Drugs		Resveratrol Selisistat Cambinol
Diseases
GWAS		Atrial fibrillation ( 30061737) Chronotype ( 30696823) Diverticular disease ( 30177863) Molybdenum levels ( 26025379) Pulse pressure ( 30224653)	Response to bupropion and depression ( 27622933) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		63 interacting genes: AFP AKT1 AR ARNTL BCL11A BHLHE41 BRIP1 CDK6 CENATAC CHFR CLOCK CSNK2B CTTN E2F1 EP300 ESRRA EZH2 FOS FOXM1 FOXO1 FOXO3 GAPDH H1-5 H3C1 HES1 HEY2 HIC1 HIPK2 HNF4A HOXB9 MAPK8 MAPT MPHOSPH8 MYCN NBN NDN NMNAT1 NR1H2 NR1H3 NR1H4 PARP1 PML PPARA PPARG PPARGC1A PRMT1 PSME3 RARA RELA RICTOR RRP8 SATB1 SETD7 SMAD7 SNW1 STK11 STK4 SUMO2 TP53 TP73 TRIM28 UBE2I VDR	22 interacting genes: BHLHE40 CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DELEC1 FBXW11 GSK3B MYOD1 NONO PER2 PPP2CB PPP2R1B PPP2R5E RASD1 RORA RORC SIRT1 WDR5
Entrez ID		23411	79365
HPRD ID		08381	16204
Ensembl ID		ENSG00000096717	ENSG00000123095
Uniprot IDs		A0A024QZQ1 A8K128 B0QZ35 E9PC49 Q96EB6	A0A024RAV8 Q8TAT1 Q9C0J9
PDB IDs		4I5I 4IF6 4IG9 4KXQ 4ZZH 4ZZI 4ZZJ 5BTR
Enriched GO Terms of Interacting Partners?
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