SIRT1 and EZH2

  • Data Source:
  • BioGRID (enzymatic study)

SIRT1

EZH2

Description sirtuin 1 enhancer of zeste 2 polycomb repressive complex 2 subunit
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Chronotype ( 30696823)
  • Colorectal or endometrial cancer ( 26621817)
  • Crohn's disease ( 28067908)
  • Familial squamous cell lung carcinoma ( 29924316)
  • Height ( 25282103 31562340)
  • Inflammatory bowel disease ( 28067908)
  • Mean reticulocyte volume ( 32888494)
  • Mean spheric corpuscular volume ( 32888494)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes 63 interacting genes: AFP AKT1 AR ARNTL BCL11A BHLHE41 BRIP1 CDK6 CENATAC CHFR CLOCK CSNK2B CTTN E2F1 EP300 ESRRA EZH2 FOS FOXM1 FOXO1 FOXO3 GAPDH H1-5 H3C1 HES1 HEY2 HIC1 HIPK2 HNF4A HOXB9 MAPK8 MAPT MPHOSPH8 MYCN NBN NDN NMNAT1 NR1H2 NR1H3 NR1H4 PARP1 PML PPARA PPARG PPARGC1A PRMT1 PSME3 RARA RELA RICTOR RRP8 SATB1 SETD7 SMAD7 SNW1 STK11 STK4 SUMO2 TP53 TP73 TRIM28 UBE2I VDR 77 interacting genes: AKT1 AR ATP1A1 ATP1B1 ATRX BCL11A BRCA1 C7orf25 CCDC85B CDK2 CDK6 CDKN2B-AS1 CEP63 CRY2 DELEC1 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 FBXW7 GADD45G GTF3C1 H1-1 H3-4 H3C1 HDAC1 HOTAIR JAK2 KAT2B KLHDC2 KRTAP10-9 LATS2 MAP3K20 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 MELK MUC1 MYCN NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRDM14 PRMT5 PSMB6 RASA1 RBL2 RELA RELB RIN3 RPN2 RPS6KA5 SIRT1 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 TRIM55 TRIM63 USP1 VAV1 WDR61 WSB2 ZMYND11
Entrez ID 23411 2146
HPRD ID 08381 03342
Ensembl ID ENSG00000096717 ENSG00000106462
Uniprot IDs A0A024QZQ1 A8K128 B0QZ35 E9PC49 Q96EB6 A0A090N8E9 Q15910 S4S3R8
PDB IDs 4I5I 4IF6 4IG9 4KXQ 4ZZH 4ZZI 4ZZJ 5BTR 2C6V 4MI0 4MI5 5GSA 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5LS6 5U5T 5U62 5WG6 5WUK 6C23 6C24 6P5L 6U4Y
Enriched GO Terms of Interacting Partners?
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