U2SURP and TBC1D4

Data Source:
BioGRID (two hybrid)

		U2SURP	TBC1D4
Description		U2 snRNP associated SURP domain containing	TBC1 domain family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytosol Vesicle
	Molecular Function	RNA Binding Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome	Intracellular Protein Transport Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus Activation Of GTPase Activity
Pathways		mRNA Splicing - Major Pathway	Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Urate levels ( 31578528)	Diabetic retinopathy ( 23562823) Eosinophil counts ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		60 interacting genes: CTNNBL1 DDX42 MIR1-1 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR143 MIR145 MIR155 MIR15B MIR18A MIR18B MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRPF40A TBC1D4 TERT TRA2A	16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1
Entrez ID		23350	9882
HPRD ID		19056	18164
Ensembl ID		ENSG00000163714	ENSG00000136111
Uniprot IDs		O15042	A0A3B3IRT3 O60343
PDB IDs			3QYB
Enriched GO Terms of Interacting Partners?
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