FLT1 and NRP2

Data Source:
HPRD (in vivo)

		FLT1	NRP2
Description		fms related receptor tyrosine kinase 1	neuropilin 2
Image
GO Annotations	Cellular Component	Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Receptor Complex	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane Axon Glutamatergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Placental Growth Factor-activated Receptor Activity	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Angiogenesis Hematopoietic Progenitor Cell Differentiation Monocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis Negative Regulation Of Vascular Endothelial Cell Proliferation Hyaloid Vascular Plexus Regression	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Septum Morphogenesis Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Viral Process Facial Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Trigeminal Ganglion Development Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Cellular Response To Leukemia Inhibitory Factor
Pathways		Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization	Neurophilin interactions with VEGF and VEGFR NrCAM interactions
Drugs		Sorafenib Sunitinib Vatalanib TG-100801 OSI-930 Denibulin ABT-869 IMC-1C11 Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib Lenvatinib Nintedanib Polaprezinc Foreskin fibroblast (neonatal) Fostamatinib Selpercatinib
Diseases
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Birth weight ( 31043758) Body mass index ( 26426971) Cognitive performance ( 19734545) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 23364394) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549)	Blood protein levels ( 30072576 29875488) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132) Neuropathy x type 2 diabetes interaction ( 32541925)
Interacting Genes		25 interacting genes: ATR CRK CTNNB1 FYN GRB2 KDR NCK1 NEDD4 NRP1 NRP2 PGF PIK3R1 PLCG1 PLCG2 PTK2 PTK2B PTPN11 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1	11 interacting genes: FLT1 L1CAM NRP1 PGF PLXNA1 PLXNB1 SEMA3B SEMA3C SEMA3F SEMA4F VEGFA
Entrez ID		2321	8828
HPRD ID		01297	03643
Ensembl ID		ENSG00000102755	ENSG00000118257
Uniprot IDs		L7RSL3 P17948	O60462 Q7Z3T9
PDB IDs		1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5ABD 5EX3 5T89	2QQJ 2QQK 2QQL 2QQO 4QDQ 4QDR 4QDS 5DN2 5DQ0 6GH8
Enriched GO Terms of Interacting Partners?
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