FLT1 and SHC2

Data Source:
BioGRID (two hybrid, two hybrid)

		FLT1	SHC2
Description		fms related receptor tyrosine kinase 1	SHC adaptor protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Receptor Complex	Cellular_component Cytosol Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Placental Growth Factor-activated Receptor Activity	Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding
	Biological Process	Angiogenesis Hematopoietic Progenitor Cell Differentiation Monocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis Negative Regulation Of Vascular Endothelial Cell Proliferation Hyaloid Vascular Plexus Regression	MAPK Cascade Activation Of MAPK Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways		Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization	Signalling to RAS Signalling to RAS VEGFA-VEGFR2 Pathway RAF/MAP kinase cascade
Drugs		Sorafenib Sunitinib Vatalanib TG-100801 OSI-930 Denibulin ABT-869 IMC-1C11 Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib Lenvatinib Nintedanib Polaprezinc Foreskin fibroblast (neonatal) Fostamatinib Selpercatinib
Diseases
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Birth weight ( 31043758) Body mass index ( 26426971) Cognitive performance ( 19734545) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 23364394) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549)	Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		25 interacting genes: ATR CRK CTNNB1 FYN GRB2 KDR NCK1 NEDD4 NRP1 NRP2 PGF PIK3R1 PLCG1 PLCG2 PTK2 PTK2B PTPN11 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1	12 interacting genes: EGFR ERBB2 ERBB3 ERBB4 FLT1 GRB2 KDR KIT MET NTRK1 NTRK2 NTRK3
Entrez ID		2321	25759
HPRD ID		01297	19296
Ensembl ID		ENSG00000102755	ENSG00000129946
Uniprot IDs		L7RSL3 P17948	P98077
PDB IDs		1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5ABD 5EX3 5T89
Enriched GO Terms of Interacting Partners?
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