DCUN1D4 and UBE2M

Data Source:
BioGRID (pull down)

		DCUN1D4	UBE2M
Description		defective in cullin neddylation 1 domain containing 4	ubiquitin conjugating enzyme E2 M
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity
	Biological Process	Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Neddylation	Cellular Protein Modification Process Protein Phosphopantetheinylation Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation
Pathways		Neddylation	TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Familial squamous cell lung carcinoma ( 29924316) Height ( 28552196)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		7 interacting genes: CAND1 CUL2 CUL3 CUL4A CUL4B UBE2M VAV2	30 interacting genes: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3
Entrez ID		23142	9040
HPRD ID		13791	04414
Ensembl ID		ENSG00000109184	ENSG00000130725
Uniprot IDs		B4DH26 Q92564	A0A024R4T4 P61081
PDB IDs		5V89	1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O
Enriched GO Terms of Interacting Partners?
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