UBE2M and SENP8

Data Source:
BioGRID (enzymatic study)

		UBE2M	SENP8
Description		ubiquitin conjugating enzyme E2 M	SUMO peptidase family member, NEDD8 specific
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity	Protein Binding NEDD8-specific Protease Activity
	Biological Process	Cellular Protein Modification Process Protein Phosphopantetheinylation Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation	Protein Deubiquitination Post-translational Protein Modification
Pathways		TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	UCH proteinases Neddylation
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Metabolite levels (HVA/MHPG ratio) ( 23319000)
Interacting Genes		30 interacting genes: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3	15 interacting genes: CHN2 COPS2 CUL1 CUL2 CUL4A GPS1 HSPA4 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28
Entrez ID		9040	123228
HPRD ID		04414	09784
Ensembl ID		ENSG00000130725	ENSG00000166192
Uniprot IDs		A0A024R4T4 P61081	A8K8D3 Q96LD8
PDB IDs		1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O	1XT9 2BKQ 2BKR
Enriched GO Terms of Interacting Partners?
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