DCUN1D4 and CAND1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DCUN1D4	CAND1
Description		defective in cullin neddylation 1 domain containing 4	cullin associated and neddylation dissociated 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus	Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cullin-RING Ubiquitin Ligase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Protein Binding TBP-class Protein Binding
	Biological Process	Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Neddylation	Cellular Iron Ion Homeostasis SCF Complex Assembly Protein Ubiquitination Cell Differentiation Negative Regulation Of Catalytic Activity Neutrophil Degranulation Post-translational Protein Modification Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Pathways		Neddylation	Neutrophil degranulation Neddylation Iron uptake and transport
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Familial squamous cell lung carcinoma ( 29924316) Height ( 28552196)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Expressive vocabulary in infants ( 25226531) HDL cholesterol levels ( 32203549) Hippocampal atrophy ( 19668339) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: CAND1 CUL2 CUL3 CUL4A CUL4B UBE2M VAV2	18 interacting genes: CA9 CNOT3 CUL1 CUL2 CUL3 CUL4A CUL4B DCUN1D1 DCUN1D2 DCUN1D4 DCUN1D5 DUX4 LNPK MTNR1A RBX1 SKP1 SRPK2 UBE2M
Entrez ID		23142	55832
HPRD ID		13791	06983
Ensembl ID		ENSG00000109184	ENSG00000111530
Uniprot IDs		B4DH26 Q92564	Q86VP6
PDB IDs		5V89	1U6G 4A0C
Enriched GO Terms of Interacting Partners?
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