MAST2 and TPM2

Data Source:
BioGRID (two hybrid)

		MAST2	TPM2
Description		microtubule associated serine/threonine kinase 2	tropomyosin 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Microtubule Cytoskeleton	Cytosol Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Phosphatase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Actin Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Peptidyl-serine Phosphorylation Regulation Of Interleukin-12 Production Intracellular Signal Transduction Spermatid Differentiation	Muscle Contraction Actin Filament Organization Muscle Filament Sliding Regulation Of ATPase Activity
Pathways			Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases			Cap myopathy Distal arthrogryposis (DA) Nemaline myopathy
GWAS		Blood protein levels ( 28240269) Body mass index ( 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Granulocyte count ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Red blood cell count ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Type 2 diabetes ( 32499647)	Immature fraction of reticulocytes ( 32888494) Platelet count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: ACTN2 APP CDHR2 DYNLL1 MXRA7 PTEN RPS27A RPS6KA1 SH3GL2 SLC34A1 SLC9A3 SMN1 SNTB2 SRPK2 STK36 SUMO2 TK1 TPM1 TPM2 TPM3 TRAF2 TRAF6 TTN ZNF417	22 interacting genes: ABI2 ACTA1 ACTB FARS2 GRK2 JUN MAST2 MESD MRFAP1 NEB PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL SNAPIN TFPT TPM1 ZNF229 ZNF620 ZNF785
Entrez ID		23139	7169
HPRD ID		11294	11768
Ensembl ID		ENSG00000086015	ENSG00000198467
Uniprot IDs		A0A669KBJ4 Q6P0Q8	A7XZE4 P07951 Q5TCU3 V9HW25
PDB IDs		2KQF 2KYL
Enriched GO Terms of Interacting Partners?
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