TPM2 and S100A4

Data Source:
HPRD (in vitro)

		TPM2	S100A4
Description		tropomyosin 2	S100 calcium binding protein A4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton	Extracellular Region Extracellular Space Nucleus Neuron Projection Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	RNA Binding Actin Binding Calcium Ion Binding Protein Binding Identical Protein Binding Transition Metal Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Muscle Contraction Actin Filament Organization Muscle Filament Sliding Regulation Of ATPase Activity	Epithelial To Mesenchymal Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs			Trifluoperazine Copper
Diseases		Cap myopathy Distal arthrogryposis (DA) Nemaline myopathy
GWAS		Immature fraction of reticulocytes ( 32888494) Platelet count ( 32888494) White blood cell count ( 32888494)	Blood protein levels ( 29875488) Pulse pressure ( 30578418)
Interacting Genes		22 interacting genes: ABI2 ACTA1 ACTB FARS2 GRK2 JUN MAST2 MESD MRFAP1 NEB PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL SNAPIN TFPT TPM1 ZNF229 ZNF620 ZNF785	28 interacting genes: ACTA1 ANXA2 BAG6 CCN3 CEP20 EGFR FCGR3A HSPB1 MDM2 METAP2 MYH10 MYH2 MYH4 MYH9 PPFIBP1 RHOU S100A1 S100B S100P SEPTIN2 SEPTIN6 SEPTIN7 SMAD3 SRPK2 TP53 TPM2 TPM3 UNC119
Entrez ID		7169	6275
HPRD ID		11768	15914
Ensembl ID		ENSG00000198467	ENSG00000196154
Uniprot IDs		A7XZE4 P07951 Q5TCU3 V9HW25	P26447
PDB IDs			1M31 2LNK 2MRD 2Q91 3C1V 3CGA 3KO0 3M0W 3ZWH 4CFQ 4CFR 4ETO 4HSZ 5LPU 6T58
Enriched GO Terms of Interacting Partners?
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