FNBP1 and ARHGAP17

Data Source:
HPRD (in vitro)

		FNBP1	ARHGAP17
Description		formin binding protein 1	Rho GTPase activating protein 17
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle	Intracellular Anatomical Structure Nucleoplasm Cytosol Plasma Membrane Bicellular Tight Junction
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Endocytosis Signal Transduction Membrane Organization	Actin Filament Organization Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Actin Cytoskeleton Organization Regulation Of Rac Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Clathrin-mediated endocytosis	Rho GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales) ( 33208821) LDL peak particle diameter (total fat intake interaction) ( 26112879) Pediatric autoimmune diseases ( 26301688) Physiological dysregulation (Mahalanobis distance) ( 32235003)	Appendicular lean mass ( 33097823) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)
Interacting Genes		13 interacting genes: AGTR1 AKAP9 ARHGAP17 CBL CDC42 DNM1 FASLG ITSN1 PDE6G RND2 SNX2 TNKS WASL	16 interacting genes: ABL1 APP BTK CDC42 CRK CTTN DNMBP FNBP1 GRB2 LCK PACSIN1 PIK3R1 RAC1 SH3GLB1 SRC TRIP10
Entrez ID		23048	55114
HPRD ID		10446	12207
Ensembl ID		ENSG00000187239	ENSG00000140750
Uniprot IDs		B7ZL13 B7ZL14 Q96RU3	Q68EM7
PDB IDs		2EFL
Enriched GO Terms of Interacting Partners?
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