KDM1A and CEP70

Data Source:
BioGRID (two hybrid)

		KDM1A	CEP70
Description		lysine demethylase 1A	centrosomal protein 70
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex DNA Repair Complex	Centrosome Cytosol
	Molecular Function	RNA Polymerase II Transcription Factor Binding P53 Binding Chromatin Binding Protein Binding Transcription Factor Binding Oxidoreductase Activity Enzyme Binding Nuclear Receptor Coactivator Activity Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-K9 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific) Telomeric DNA Binding MRF Binding Flavin Adenine Dinucleotide Binding Androgen Receptor Binding Telomeric Repeat-containing RNA Binding Promoter-specific Chromatin Binding	Protein Binding Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Protein Demethylation Blood Coagulation Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Neuron Projection Development Cerebral Cortex Development Negative Regulation Of Protein Binding Histone H3-K9 Demethylation Positive Regulation Of Histone Ubiquitination Cellular Response To UV Histone H3-K4 Demethylation Positive Regulation Of Chromatin Binding Neuron Maturation Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Size Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Guanine Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Muscle Cell Development Response To Fungicide Cellular Response To CAMP Cellular Response To Gamma Radiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cellular Protein Localization Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Cytoskeleton Organization Ciliary Basal Body-plasma Membrane Docking
Pathways		HDACs deacetylate histones HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Regulation of PTEN gene transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Gamma glutamyl transferase levels ( 29403010) Global electrical heterogeneity phenotypes ( 29622589) Pulse pressure ( 27841878) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Male-pattern baldness ( 28196072)
Interacting Genes		265 interacting genes: AKAP9 ANKEF1 ANKRD23 AP1G2 AR ARHGAP15 ARHGAP29 ASB10 ASB3 ASCC2 ATP5MF ATP6V1B1 BAHD1 BAIAP2 BATF BCAT1 BIRC2 BLZF1 BMP3 BRCA1 C18orf54 C4orf17 C8orf48 C8orf74 CAGE1 CARD10 CCDC121 CCDC14 CCDC172 CCDC33 CCDC74A CCDC74B CCDC90B CDC23 CDC5L CDCA4 CDCA5 CENPQ CEP162 CEP57 CEP70 CEP76 CFAP100 COIL CRBN CRLF3 CSNK2A1 CSNK2A2 CTBP1 DBF4B DNAAF4 DNAJA3 DNTTIP1 E2F1 ECI2 ELOF1 EXOC1 EXOC7 FAM161A FAM204A FAM9A FIGNL1 FYCO1 FYN GABPB2 GAS8 GATA3 GCC1 GDF9 GLYR1 GOLGA2 GOLGA6A GPATCH2L GSK3B GSTCD GTPBP2 H3-4 H3-5 H3C1 H3C14 HAUS1 HAUS3 HAUS6 HDAC1 HESX1 HOMER3 HOXA1 ID2 IFI35 IGFBP4 IK IKBIP IL16 IMMT INSM1 INTS2 ISL1 ITGB3BP ITSN2 JRK KANSL1 KASH5 KDM5B KIAA0408 KIFC3 KLC3 KLF3 KLHDC4 KRT15 KRT17 KRT19 KRT222 KRT31 KRT33B KRT35 KRT38 KRT39 KRT40 KRT6A KRT6B KRT7 L3MBTL3 LENG8 LINC02875 LOXL4 LZTS1 MALT1 MBD3 MBD4 MCPH1 MCRS1 METTL27 MLC1 MNS1 MTA3 MTF2 MTMR9 MTO1 MYC MYLIP NBPF15 NBPF26 NDUFA8 NDUFS1 NECAB2 NEFL NF2 NFE2L2 NMI NOSTRIN NR1H2 NR1H3 NR2C2 NR2E1 NRBF2 ODAD3 OFCC1 OIP5 OPA3 OTUB1 PBX4 PDCD5 PDE4DIP PEX7 PFDN5 PHC2 PHF19 PHF20L1 PHF21A PMF1 PNKP PPARD PPM1D PPP1R12A PRDM1 PRIM2 PSMC1 PSMC3 PTEN RASSF1 RASSF2 RASSF3 RASSF8 RCOR1 RCOR3 RIOK1 RNF10 RNF168 RPRD1A SAMD3 SEPTIN6 SERGEF SETDB1 SF3B2 SH3GLB2 SLU7 SMAD9 SMARCD1 SMN1 SNF8 SNX15 SOCS6 SPATA22 SPATA24 SPICE1 SPRY2 SPSB1 SPZ1 SRGAP3 SSX2IP STAT3 STX11 STX19 SUMO2 SUV39H1 TACC1 TADA3 TAL1 TDO2 TEDC2 TERF1 TEX35 TEX9 TFIP11 TLE5 TMEM266 TNFAIP1 TNNT2 TP53 TP53BP1 TP53BP2 TRAF4 TRIM39 TRIM54 TSACC TSC1 TTC23 TTC33 UBA3 UBASH3B UBE2I UCHL5 UNC119 UNKL USP28 USP7 VPS11 VPS37A VPS37B WASHC3 WDR83 ZBED1 ZBTB24 ZBTB39 ZCCHC17 ZFP28 ZNF280A ZNF333 ZNF436 ZNF451 ZNF480 ZNF581 ZNF641 ZNF71 ZNF829	242 interacting genes: ABT1 AGBL2 AKAP17A ARHGEF3 ARMCX1 ATP5PO ATXN7 BARD1 BAZ2B BEX2 BRD1 BRMS1 BRMS1L BRPF1 BYSL C1orf35 C7orf25 C8orf33 CARD9 CAVIN3 CBX8 CCDC187 CCDC85B CDC37 CDC73 CDCA7L CEP57L1 CFAP53 CLPB COIL CWF19L2 DAXX DAZAP2 DDX41 DDX6 DNAJB11 DNTTIP2 DVL3 EAF1 EBNA1BP2 EIF3D ELOA ELOA2 EMD EMP1 ENKD1 ERCC3 FAM118B FAM124A FAM133A FAM13C FAM161A FAM161B FAM214B FAM90A1 GADD45GIP1 GAS8 GATAD2B GCC1 GEM GLYCTK GPATCH2L GPATCH4 GPX7 GSE1 HAUS1 HDAC4 HDAC6 HIC2 HMGB4 HOXB5 HOXC8 HSPD1 IK INO80B INPP5J IPCEF1 IQCE IQUB ITPKB KANK2 KANSL1 KAT14 KAT5 KAT7 KDM1A KRI1 KRT31 LAMTOR5 LCOR LENG1 LENG8 LIN37 LNX1 MAB21L2 MAGOH MBD3 MCM10 MCRS1 MEST METTL17 MFAP1 MKRN3 MRPL44 NEBL NIPSNAP3A NKAP NKAPD1 NOL12 NOP2 NOP53 NOXA1 NRIP1 NTAQ1 NUSAP1 ODAD4 PAM16 PIBF1 PIMREG PKN1 PLA2G2A PPFIA1 PPIG PPP1R16B PPP1R18 PRKRIP1 PRPF18 PRPF3 PRPF31 PSMA1 PSORS1C2 RASSF10 RBM10 RCOR3 RHPN1 RNF169 RNF6 RPL13 SCNM1 SEC14L1 SERPINH1 SETD5 SFR1 SH2D4A SLU7 SMARCE1 SNRPD2 SNW1 SOD2 SPANXN3 SRGN SSX3 STK25 STMN2 SUV39H1 SUV39H2 SYT17 SYTL4 SYTL5 TAF1D TBC1D22B TBC1D30 TCAF1 TCEANC TEAD4 TLK2 TRAF3IP3 TRIM29 TRIM3 TRIM42 TSFM TSGA10IP TSHZ3 TTLL10 TXLNB TXN2 USP2 UTP11 UTP14A UTP14C UTP25 UTP3 VXN WT1 YJU2 ZBTB16 ZBTB24 ZBTB4 ZBTB47 ZBTB48 ZBTB49 ZBTB8A ZCCHC10 ZFC3H1 ZFHX3 ZFP1 ZFP91 ZGPAT ZNF136 ZNF140 ZNF148 ZNF165 ZNF169 ZNF17 ZNF20 ZNF202 ZNF227 ZNF239 ZNF264 ZNF266 ZNF302 ZNF329 ZNF35 ZNF366 ZNF408 ZNF410 ZNF417 ZNF426 ZNF433 ZNF439 ZNF490 ZNF491 ZNF555 ZNF557 ZNF572 ZNF574 ZNF578 ZNF587 ZNF599 ZNF607 ZNF648 ZNF669 ZNF688 ZNF696 ZNF775 ZNF777 ZNF785 ZNF835 ZNF860 ZSCAN12 ZSCAN21 ZSCAN23
Entrez ID		23028	80321
HPRD ID		09800	16779
Ensembl ID		ENSG00000004487	ENSG00000114107
Uniprot IDs		O60341	A0A140VJG2 B7Z2D2 Q8NHQ1
PDB IDs		2COM 2DW4 2EJR 2H94 2HKO 2IW5 2L3D 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 2Z3Y 2Z5U 3ABT 3ABU 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1 4BAY 4CZZ 4KUM 4UV8 4UV9 4UVA 4UVB 4UVC 4UXN 4XBF 5AFW 5H6Q 5H6R 5IT3 5L3B 5L3C 5L3D 5L3E 5L3F 5L3G 5LBQ 5LGN 5LGT 5LGU 5LHG 5LHH 5LHI 5X60 5YJB 6E1F 6K3E 6KGK 6KGL 6KGM 6KGN 6KGO 6KGP 6KGQ 6KGR 6NQM 6NQU 6NR5 6S35 6TE1 6VYP 6W4K 7JJL 7JJM 7JK7
Enriched GO Terms of Interacting Partners?
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