ADGRL1 and SHANK1

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		ADGRL1	SHANK1
Description		adhesion G protein-coupled receptor L1	SH3 and multiple ankyrin repeat domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Integral Component Of Membrane Axon Growth Cone Presynaptic Membrane Neuron Projection Synapse	Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Neuron Projection Dendritic Spine Postsynaptic Membrane Excitatory Synapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding	Protein Binding Protein C-terminus Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding
	Biological Process	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Synapse Maturation	Behavior Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Brain Morphogenesis Neuromuscular Process Controlling Balance Determination Of Affect Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Maturation Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS			Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)
Interacting Genes		9 interacting genes: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2	19 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 USP8
Entrez ID		22859	50944
HPRD ID		14305	05413
Ensembl ID		ENSG00000072071	ENSG00000161681
Uniprot IDs		O94910	H9KV90 Q9Y566
PDB IDs			6CPI
Enriched GO Terms of Interacting Partners?
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