ADGRL1 and SHANK2

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ADGRL1	SHANK2
Description		adhesion G protein-coupled receptor L1	SH3 and multiple ankyrin repeat domains 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Integral Component Of Membrane Axon Growth Cone Presynaptic Membrane Neuron Projection Synapse	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Synapse Maturation	Synapse Assembly Behavior Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		9 interacting genes: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2	19 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		22859	22941
HPRD ID		14305	04479
Ensembl ID		ENSG00000072071	ENSG00000162105
Uniprot IDs		O94910	A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8
PDB IDs
Enriched GO Terms of Interacting Partners?
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