SHANK1 and ADGRL2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SHANK1	ADGRL2
Description		SH3 and multiple ankyrin repeat domains 1	adhesion G protein-coupled receptor L2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Neuron Projection Dendritic Spine Postsynaptic Membrane Excitatory Synapse	Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection Glutamatergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding	G Protein-coupled Receptor Activity Latrotoxin Receptor Activity Carbohydrate Binding
	Biological Process	Behavior Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Brain Morphogenesis Neuromuscular Process Controlling Balance Determination Of Affect Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Maturation Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Brain Development Response To Bacterium Synapse Organization Positive Regulation Of Synapse Assembly
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)	Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Low density lipoprotein cholesterol levels ( 30498476)
Interacting Genes		19 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 USP8	3 interacting genes: NCK1 SHANK1 SHANK2
Entrez ID		50944	23266
HPRD ID		05413	06116
Ensembl ID		ENSG00000161681	ENSG00000117114
Uniprot IDs		H9KV90 Q9Y566	A0A6I8PTT2 O95490
PDB IDs		6CPI
Enriched GO Terms of Interacting Partners?
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