SHANK2 and SLC9A3

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SHANK2	SLC9A3
Description		SH3 and multiple ankyrin repeat domains 2	solute carrier family 9 member A3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Plasma Membrane Brush Border Cell Surface Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Protein Binding Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity PDZ Domain Binding
	Biological Process	Synapse Assembly Behavior Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential	Ion Transport Regulation Of Intracellular PH Potassium Ion Transmembrane Transport Anion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Sodium/Proton exchangers
Drugs			Tenapanor
Diseases
GWAS		Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Estimated glomerular filtration rate ( 31152163) Lung disease severity in cystic fibrosis ( 26417704) Ulcerative colitis ( 28067908 23128233)
Interacting Genes		19 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2	8 interacting genes: CHP1 CHP2 LRP2 MAST2 PDZK1 SHANK2 SLC9A3R1 SLC9A3R2
Entrez ID		22941	6550
HPRD ID		04479	01660
Ensembl ID		ENSG00000162105	ENSG00000066230
Uniprot IDs		A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8	P48764
PDB IDs
Enriched GO Terms of Interacting Partners?
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