XRN2 and BFSP1

Data Source:
BioGRID (proximity labelling technology)

		XRN2	BFSP1
Description		5'-3' exoribonuclease 2	beaded filament structural protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Cytoplasm Intermediate Filament Plasma Membrane Cell Cortex
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding	Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Biological_process Intermediate Filament Organization Cell Maturation Lens Fiber Cell Development
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) ( 30920136) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2	12 interacting genes: BFSP2 BYSL CCHCR1 EMILIN1 KIFC3 KRT27 LINC00839 NUP62 SNAPIN USHBP1 VIM ZWINT
Entrez ID		22803	631
HPRD ID		10309	04494
Ensembl ID		ENSG00000088930	ENSG00000125864
Uniprot IDs		B4DZC3 Q9H0D6	B7Z999 B7ZAD2 Q12934
PDB IDs
Enriched GO Terms of Interacting Partners?
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