XRN2 and ATRN

Data Source:
BioGRID (two hybrid)

		XRN2	ATRN
Description		5'-3' exoribonuclease 2	attractin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Basement Membrane Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding	Carbohydrate Binding Signaling Receptor Activity
	Biological Process	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Inflammatory Response Response To Oxidative Stress Animal Organ Morphogenesis Tissue Development Cell Migration Cerebellum Development Substrate Adhesion-dependent Cell Spreading Regulation Of Multicellular Organism Growth Myelination Pigmentation
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Asthma ( 29273806) Diisocyanate-induced asthma ( 25918132) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Night sleep phenotypes ( 27126917) Postcentral gyrus volume ( 31530798) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2	3 interacting genes: COPS5 XRN2 ZNF408
Entrez ID		22803	8455
HPRD ID		10309	04388
Ensembl ID		ENSG00000088930	ENSG00000088812
Uniprot IDs		B4DZC3 Q9H0D6	B4DZ36 O75882
PDB IDs
Enriched GO Terms of Interacting Partners?
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