XRN2 and CTSC

Data Source:
BioGRID (two hybrid)

		XRN2	CTSC
Description		5'-3' exoribonuclease 2	cathepsin C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Golgi Membrane Extracellular Region Extracellular Space Nucleoplasm Lysosome Endoplasmic Reticulum Lumen Centrosome Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding	Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Dipeptidyl-peptidase Activity Peptidase Activator Activity Involved In Apoptotic Process Phosphatase Binding Chloride Ion Binding Identical Protein Binding Protein Self-association Chaperone Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	T Cell Mediated Cytotoxicity Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Immune Response Aging Response To Organic Substance Negative Regulation Of Myelination Neutrophil Degranulation COPII Vesicle Coating Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Microglial Cell Activation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol	COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Neutrophil degranulation
Drugs
Diseases			Papillon-Lefevre syndrome Haim-Munk syndrome
GWAS		Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2	3 interacting genes: CAPN1 CTSL XRN2
Entrez ID		22803	1075
HPRD ID		10309	03841
Ensembl ID		ENSG00000088930	ENSG00000109861
Uniprot IDs		B4DZC3 Q9H0D6	P53634
PDB IDs			1K3B 2DJF 2DJG 3PDF 4CDC 4CDD 4CDE 4CDF 4OEL 4OEM
Enriched GO Terms of Interacting Partners?
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