GPC4 and PTPRD

Data Source:
BioGRID (pull down)

		GPC4	PTPRD
Description		glypican 4	protein tyrosine phosphatase receptor type D
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Lysosomal Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome Glutamatergic Synapse Anchored Component Of Presynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Protein Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Regulation Of Signal Transduction Wnt Signaling Pathway Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synaptic Membrane Adhesion Regulation Of Protein Localization To Membrane Regulation Of Presynapse Assembly	Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Differentiation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Dendrite Morphogenesis Regulation Of Immune Response Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Presynaptic Membrane Assembly Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport	Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
Drugs
Diseases
GWAS			Adult body size ( 32376654) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Anxiety and major depressive disorder ( 24047446) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bitter alcoholic beverage consumption ( 31046077) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Cardiac Troponin-T levels ( 31014085) Cardiorespiratory fitness (800m run time) ( 32572135) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Early age at menarche ( 29773799) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Epilepsy (remission after treatment) ( 23962720) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Gait rhythm ( 26219847) Glycine levels ( 31070104) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Intracranial aneurysm ( 29531279) Lean body mass ( 28552196) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Loneliness (multivariate analysis) ( 27629369) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 29773799 25231870) Metabolite levels ( 23823483) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Moderate-to-late spontaneous preterm birth ( 31194736) Modic changes ( 30808802) Mood instability ( 29187730) Morning person ( 30696823) Myopia (pathological) ( 23049088) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Non-response to antidepressants and depression ( 27622933) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 24821223) Opioid use cessation ( 31936517) Palmitic acid (16:0) levels ( 23362303) Parkinson's disease progression (motor) ( 33111402) Partial epilepsies ( 20522523) Pelvic organ prolapse (moderate/severe) ( 26545240) Personality dimensions ( 23903073) Pit-and-Fissure caries ( 24556642) Plasma clusterin levels ( 26545630) Platelet aggregation ( 20526338) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Resistant hypertension ( 30237584) Resting-state electroencephalogram vigilance ( 29703947) Restless legs syndrome ( 18660810 29029846 21779176) Short-term memory (digit-span task) ( 30741946) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure ( 30224653 27841878) Temperament ( 22832960) Third ventricle volume ( 31530798) Type 2 diabetes ( 21647700 20174558) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) White matter hyperintensities in ischemic stroke ( 26674333)
Interacting Genes		10 interacting genes: ABHD17A ACP5 AKAP9 CCNC COL18A1 FGF2 PICK1 PTEN PTPRD PTPRF	34 interacting genes: ABLIM1 AURKA BMX CSNK1D CSNK1E DDX17 DDX54 EPHA8 GPC4 IL1RAP IRS1 MARK2 MATK MTNR1A MTNR1B MTSS1 NEK1 NEK2 NEK6 PAK6 PLK1 PPFIA1 PPFIA2 PPFIA3 PTPRA PTPRE PTPRF PTPRS SCEL SLAIN2 SLITRK1 SMTNL2 TBK1 TSSK2
Entrez ID		2239	5789
HPRD ID		02160	03358
Ensembl ID		ENSG00000076716	ENSG00000153707
Uniprot IDs		O75487	P23468 Q2HXI4 Q3KPI9 Q59H90
PDB IDs			1X5Z 2DLH 2YD6 2YD7 4RCA 5WY8 5XNP
Enriched GO Terms of Interacting Partners?
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