PTPRD and SLITRK1

Data Source:
BioGRID (pull down)

		PTPRD	SLITRK1
Description		protein tyrosine phosphatase receptor type D	SLIT and NTRK like family member 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane	Extracellular Region Plasma Membrane Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Cell Adhesion Molecule Binding	Protein Binding
	Biological Process	Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Differentiation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Dendrite Morphogenesis Regulation Of Immune Response Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Presynaptic Membrane Assembly Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Axonogenesis Synapse Assembly Adult Behavior Multicellular Organism Growth Homeostatic Process Positive Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Synaptic Membrane Adhesion Regulation Of Presynapse Assembly
Pathways		Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules	Receptor-type tyrosine-protein phosphatases
Drugs
Diseases			Trichotillomania Tourette syndrome
GWAS		Adult body size ( 32376654) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Anxiety and major depressive disorder ( 24047446) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bitter alcoholic beverage consumption ( 31046077) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Cardiac Troponin-T levels ( 31014085) Cardiorespiratory fitness (800m run time) ( 32572135) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Early age at menarche ( 29773799) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Epilepsy (remission after treatment) ( 23962720) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Gait rhythm ( 26219847) Glycine levels ( 31070104) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Intracranial aneurysm ( 29531279) Lean body mass ( 28552196) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Loneliness (multivariate analysis) ( 27629369) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 29773799 25231870) Metabolite levels ( 23823483) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Moderate-to-late spontaneous preterm birth ( 31194736) Modic changes ( 30808802) Mood instability ( 29187730) Morning person ( 30696823) Myopia (pathological) ( 23049088) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Non-response to antidepressants and depression ( 27622933) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 24821223) Opioid use cessation ( 31936517) Palmitic acid (16:0) levels ( 23362303) Parkinson's disease progression (motor) ( 33111402) Partial epilepsies ( 20522523) Pelvic organ prolapse (moderate/severe) ( 26545240) Personality dimensions ( 23903073) Pit-and-Fissure caries ( 24556642) Plasma clusterin levels ( 26545630) Platelet aggregation ( 20526338) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Resistant hypertension ( 30237584) Resting-state electroencephalogram vigilance ( 29703947) Restless legs syndrome ( 18660810 29029846 21779176) Short-term memory (digit-span task) ( 30741946) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure ( 30224653 27841878) Temperament ( 22832960) Third ventricle volume ( 31530798) Type 2 diabetes ( 21647700 20174558) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) White matter hyperintensities in ischemic stroke ( 26674333)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bipolar disorder (mania) ( 23326512) Carotid intima media thickness x smoking interaction ( 32117412) Cerebral amyloid deposition (PET imaging) ( 30361487) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Hepcidin/transferrin saturation ratio ( 27846281) Heschl's gyrus morphology ( 25130324) Metabolite levels ( 23823483) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Squamous cell lung carcinoma ( 28604730) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		34 interacting genes: ABLIM1 AURKA BMX CSNK1D CSNK1E DDX17 DDX54 EPHA8 GPC4 IL1RAP IRS1 MARK2 MATK MTNR1A MTNR1B MTSS1 NEK1 NEK2 NEK6 PAK6 PLK1 PPFIA1 PPFIA2 PPFIA3 PTPRA PTPRE PTPRF PTPRS SCEL SLAIN2 SLITRK1 SMTNL2 TBK1 TSSK2	3 interacting genes: PTPRD PTPRS UBQLN2
Entrez ID		5789	114798
HPRD ID		03358	18063
Ensembl ID		ENSG00000153707	ENSG00000178235
Uniprot IDs		P23468 Q2HXI4 Q3KPI9 Q59H90	Q96PX8
PDB IDs		1X5Z 2DLH 2YD6 2YD7 4RCA 5WY8 5XNP	4RCA 4RCW
Enriched GO Terms of Interacting Partners?
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