GPC4 and ACP5

Data Source:
HPRD (in vivo)

		GPC4	ACP5
Description		glypican 4	acid phosphatase 5, tartrate resistant
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Lysosomal Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome Glutamatergic Synapse Anchored Component Of Presynaptic Membrane	Lysosome Cytosol Integral Component Of Membrane
	Molecular Function	Protein Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	Acid Phosphatase Activity Ferrous Iron Binding Ferric Iron Binding
	Biological Process	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Regulation Of Signal Transduction Wnt Signaling Pathway Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synaptic Membrane Adhesion Regulation Of Protein Localization To Membrane Regulation Of Presynapse Assembly	Ossification Riboflavin Metabolic Process Dephosphorylation Bone Resorption
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport	Vitamin B2 (riboflavin) metabolism
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488) Multiple sclerosis (severity) ( 19010793)
Interacting Genes		10 interacting genes: ABHD17A ACP5 AKAP9 CCNC COL18A1 FGF2 PICK1 PTEN PTPRD PTPRF	11 interacting genes: EGR2 GPC4 MAPK9 PDCD5 PPP2CB RPA2 SLC35F6 SNRNP40 SPP1 TNFSF10 ZBTB16
Entrez ID		2239	54
HPRD ID		02160	01374
Ensembl ID		ENSG00000076716	ENSG00000102575
Uniprot IDs		O75487	A0A024R7F8 P13686
PDB IDs			1WAR 2BQ8
Enriched GO Terms of Interacting Partners?
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