CCND3 and GC

Data Source:
BioGRID (two hybrid)

		CCND3	GC
Description		cyclin D3	GC vitamin D binding protein
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Membrane	Extracellular Region Extracellular Space Cytoplasm Cytosol Lysosomal Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding	Actin Binding Vitamin D Binding Vitamin Transmembrane Transporter Activity Calcidiol Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Signal Transduction T Cell Proliferation Regulation Of Cell Population Proliferation Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Insulin Receptor Signaling Pathway Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Transport Vitamin Transmembrane Transport Vitamin D Metabolic Process Vitamin Transport
Pathways		Transcriptional regulation of white adipocyte differentiation MAPK6/MAPK4 signaling Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Vitamin D (calciferol) metabolism
Drugs			Vitamin D
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Cardiometabolic and hematological traits ( 27668658) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549 28334899) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematological parameters ( 19820697) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 29403010 32888494 28453575 20139978 27863252 28017375 19862010) Mean corpuscular hemoglobin concentration ( 32888494 28017375) Mean corpuscular volume ( 23263863 29403010 32888494 28453575 20139978 27863252 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 21507922) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494 20139978 27863252 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)	Blood protein levels ( 29875488) Granulocyte count ( 27863252) Lymphocyte counts ( 32888494) Metabolite levels ( 22916037) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Neutrophil count ( 32888494 27863252) Non-alcoholic fatty liver disease histology (other) ( 23213074) Platelet count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum 25-Hydroxyvitamin D levels ( 29545823 29325163 31841498) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum vitamin D-binding protein levels ( 24740207) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 29343764 22673963 20418485 25208829) Vitamin D levels (dietary vitamin D intake interaction) ( 29343764) White blood cell count ( 32888494 27863252)
Interacting Genes		56 interacting genes: AKAP8 APP AREG ATF5 ATP5F1C C14orf119 CASP2 CCDC13 CDK11B CDK14 CDK16 CDK18 CDK3 CDK4 CDK5 CDK6 CDKN1A CDKN1B CDKN2D CRABP2 DMRTB1 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS FHL3 GC HGS KIFC3 LSM3 MAF1 MAPK4 MAPK6 MCM10 MNS1 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL PSMC1 QKI RARA RB1 RBL2 RUNX1 SH3GLB2 SIL1 TEX11 TFIP11 TSG101 VDR	12 interacting genes: ACTA1 ACTA2 ACTC1 C3 CCND3 CDC73 CUBN GRB2 LRIF1 LRP2 PIK3R3 SERF2
Entrez ID		896	2638
HPRD ID		00452	00749
Ensembl ID		ENSG00000112576	ENSG00000145321
Uniprot IDs		B3KP19 D6RI00 P30281 Q5T8J1	P02774
PDB IDs		3G33	1J78 1J7E 1KW2 1KXP 1LOT 1MA9
Enriched GO Terms of Interacting Partners?
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