KLK3 and PTHLH

Data Source:
HPRD (in vitro)

		KLK3	PTHLH
Description		kallikrein related peptidase 3	parathyroid hormone like hormone
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Secretory Granule Protein-containing Complex Extracellular Exosome	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides	Hormone Activity Protein Binding Peptide Hormone Receptor Binding
	Biological Process	Antibacterial Peptide Production Regulation Of Systemic Arterial Blood Pressure Proteolysis Negative Regulation Of Angiogenesis Zymogen Activation Cellular Protein Metabolic Process	Skeletal System Development Osteoblast Development G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Regulation Of Gene Expression Bone Mineralization Regulation Of Chondrocyte Differentiation Negative Regulation Of Chondrocyte Differentiation CAMP Metabolic Process Negative Regulation Of Chondrocyte Development
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Mifepristone Cyproterone acetate Gallium Ga-68 gozetotide
Diseases
GWAS		Celiac disease ( 23936387) Elevated serum prostate-specific antigen levels in healthy men ( 28471803) PCA3 expression level ( 23555189) Prostate cancer ( 18264097 31562322 26034056 24753544) Prostate cancer (early onset) ( 24740154) Prostate cancer aggressiveness ( 25939597) Prostate-specific antigen levels ( 25434496 23269536 28139693 24919509) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Serum prostate-specific antigen levels ( 21160077)	Asthma and hay fever ( 24388013) Blood protein levels ( 30072576 29875488) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 23535729 23535733 27117709 31757997) Breast cancer (estrogen-receptor negative) ( 27117709) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast size ( 22747683 27182965) Height ( 31562340) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis (hip) ( 30664745)
Interacting Genes		14 interacting genes: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI	7 interacting genes: ARRB1 CDK2 IL6 KLK3 KPNB1 MTDH PTH1R
Entrez ID		354	5744
HPRD ID		01461	01348
Ensembl ID		ENSG00000142515	ENSG00000087494
Uniprot IDs		P07288 Q546G3	A0A024RB29 P12272 Q53XY9
PDB IDs		1PFA 2PSA 2ZCH 2ZCK 2ZCL 3QUM	1BZG 1ET3 1M5N 3FFD 3H3G
Enriched GO Terms of Interacting Partners?
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