CTTN and MYLK

Data Source:
HPRD (in vitro)

		CTTN	MYLK
Description		cortactin	myosin light chain kinase
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GO Annotations	Cellular Component	Ruffle Podosome Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Lamellipodium Growth Cone Site Of Polarized Growth Cortical Cytoskeleton Cortical Actin Cytoskeleton Dendritic Spine Intracellular Membrane-bounded Organelle Mitotic Spindle Midzone	Stress Fiber Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Lamellipodium Cleavage Furrow
	Molecular Function	Protein Binding Profilin Binding Cadherin Binding Actin Filament Binding	Actin Binding Protein Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Membrane Organization Dendritic Spine Maintenance Lamellipodium Organization Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Phosphorylation Muscle Contraction Smooth Muscle Contraction Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Positive Regulation Of Wound Healing
Pathways		RHO GTPases activate PAKs Clathrin-mediated endocytosis	Smooth Muscle Contraction RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs			Fostamatinib
Diseases			Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS			General cognitive ability ( 29844566)
Interacting Genes		42 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 RPL9 SDC3 SH3BP2 SHANK2 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 WASL WIPF1	15 interacting genes: ACTA1 ACTC1 APPBP2 CALM1 CAMK2G CTTN GOPC HSPB1 MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC
Entrez ID		2017	4638
HPRD ID		01268	02952
Ensembl ID		ENSG00000085733	ENSG00000065534
Uniprot IDs		A0A024R5M3 Q14247 Q53HG7	Q05B97 Q05B98 Q15746
PDB IDs		1X69 2D1X	2CQV 2K0F 2YR3 5JQA 5JTH 6C6M
Enriched GO Terms of Interacting Partners?
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