CTTN and ARHGAP8

Data Source:
HPRD (in vivo, in vitro)

		CTTN	ARHGAP8
Description		cortactin	Rho GTPase activating protein 8
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Podosome Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Lamellipodium Growth Cone Site Of Polarized Growth Cortical Cytoskeleton Cortical Actin Cytoskeleton Dendritic Spine Intracellular Membrane-bounded Organelle Mitotic Spindle Midzone	Cytosol
	Molecular Function	Protein Binding Profilin Binding Cadherin Binding Actin Filament Binding	GTPase Activator Activity Protein Binding
	Biological Process	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Membrane Organization Dendritic Spine Maintenance Lamellipodium Organization Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		RHO GTPases activate PAKs Clathrin-mediated endocytosis	Rho GTPase cycle
Drugs
Diseases
GWAS			Binge eating behaviour in bipolar disorder ( 29391396) Body mass index ( 28552196) Electroencephalographic traits in alcoholism ( 22554406) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Weight ( 28552196)
Interacting Genes		42 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 RPL9 SDC3 SH3BP2 SHANK2 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 WASL WIPF1	6 interacting genes: BNIP2 CTTN CYGB RHOA SH3GL1 ZMYND12
Entrez ID		2017	23779
HPRD ID		01268	06448
Ensembl ID		ENSG00000085733	ENSG00000241484
Uniprot IDs		A0A024R5M3 Q14247 Q53HG7	P85298 Q6PJW1
PDB IDs		1X69 2D1X
Enriched GO Terms of Interacting Partners?
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