MYLK and MLC1

Data Source:
BioGRID (enzymatic study)

		MYLK	MLC1
Description		myosin light chain kinase	modulator of VRAC current 1
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Lamellipodium Cleavage Furrow	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Integral Component Of Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Actin Binding Protein Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Metal Ion Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Phosphorylation Muscle Contraction Smooth Muscle Contraction Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Positive Regulation Of Wound Healing	Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Cellular Response To Cholesterol Caveolin-mediated Endocytosis
Pathways		Smooth Muscle Contraction RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs		Fostamatinib
Diseases		Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)	Megalencephalic leukoencephalopathy with subcortical cysts (MLC)
GWAS		General cognitive ability ( 29844566)	Acne (severe) ( 24927181) Body mass index (adult) ( 28430825)
Interacting Genes		15 interacting genes: ACTA1 ACTC1 APPBP2 CALM1 CAMK2G CTTN GOPC HSPB1 MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC	6 interacting genes: DAPK2 KDM1A MYLK PRMT6 ROCK1 TPT1
Entrez ID		4638	23209
HPRD ID		02952	05800
Ensembl ID		ENSG00000065534	ENSG00000100427
Uniprot IDs		Q05B97 Q05B98 Q15746	A0A024R4V4 Q15049
PDB IDs		2CQV 2K0F 2YR3 5JQA 5JTH 6C6M
Enriched GO Terms of Interacting Partners?
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