PEF1 and STH

Data Source:
BioGRID (two hybrid)

		PEF1	STH
Description		penta-EF-hand domain containing 1	saitohin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum COPII Vesicle Coat Cul3-RING Ubiquitin Ligase Complex Extracellular Exosome	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Identical Protein Binding Protein Heterodimerization Activity Protein Dimerization Activity Calcium-dependent Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Protein Ubiquitination COPII Vesicle Coating Response To Calcium Ion Positive Regulation Of Protein Monoubiquitination	Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Asthma ( 31959851) Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Severe aortic features in Marfan syndrome ( 30087447)	Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Brain morphology (MOSTest) ( 32665545) Handedness (Left-handed vs. non-left-handed) ( 30980028) Handedness (Right-handed vs. non-right-handed) ( 30980028) Idiopathic pulmonary fibrosis ( 24429156) Intracranial volume ( 22504418) Male-pattern baldness ( 28196072) Neurociticism ( 29500382) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Parkinson's disease ( 28892059 22438815) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Sleep duration ( 30531941) Subcortical brain region volumes ( 25607358)
Interacting Genes		40 interacting genes: AKAP8L ALG2 ANKRD10 BAG4 BPIFA1 C11orf1 CALCOCO2 CEP55 CTAG1A CTAG1B CUL3 DAZAP2 DMRTB1 EIF4G1 EWSR1 FAM168A FOXR2 HEMK1 HGS HYDIN INCA1 KLHL12 KRTAP12-1 KRTAP15-1 KRTAP19-1 MED25 METTL15 NR0B2 PDCD6 SEC24A SEC31A SMUG1 SOHLH1 SPAG8 SPG21 STH TFG VPS37C WWOX ZIC1	16 interacting genes: CSTF2 CSTF2T FRS3 MKRN3 NTAQ1 PEF1 PITX1 POGZ PRDX6 SMARCD1 SNRPC SOHLH1 SUOX TFG TLX3 VPS37C
Entrez ID		553115	246744
HPRD ID		10143	06142
Ensembl ID		ENSG00000162517	ENSG00000256762
Uniprot IDs		A0A384MQX5 Q9UBV8	Q8IWL8
PDB IDs
Enriched GO Terms of Interacting Partners?
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