DYRK1A and RBL1

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)

		DYRK1A	RBL1
Description		dual specificity tyrosine phosphorylation regulated kinase 1A	RB transcriptional corepressor like 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Nuclear Speck Axon Dendrite Ribonucleoprotein Complex	Chromatin Nucleoplasm Transcription Regulator Complex
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Self-association Tau Protein Binding Tau-protein Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding Protein Binding Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Phosphorylation Nervous System Development Circadian Rhythm Viral Process Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Microtubule Polymerization Positive Regulation Of RNA Splicing Amyloid-beta Formation Peptidyl-serine Autophosphorylation Peptidyl-tyrosine Autophosphorylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Deacetylation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Cycle Negative Regulation Of Gene Expression Viral Process Cell Differentiation Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Senescence
Pathways		G0 and Early G1	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest G1/S-Specific Transcription Cyclin D associated events in G1
Drugs		N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide Fostamatinib
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) HIV-1 replication ( 21364930) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Neutrophil count ( 32888494) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Stroke ( 30383316) White blood cell count ( 32888494)	Height ( 25429064) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 28957414)
Interacting Genes		33 interacting genes: - AMPH APP CCNL2 CLASRP CREB1 CREBBP EIF2B5 FOXO1 GLI1 H2BC3 H3C1 H4C1 ID2 KPRP LATS2 LIN52 MAPT PEA15 PHYHIP PRKN RB1 RBL1 RNF169 SF3B1 SNCA SRSF1 SRSF4 SRSF5 TROAP YWHAB YWHAE YWHAG	54 interacting genes: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F1 E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A KMT5C LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 TAF1 TOP1 TP53BP1 TSC22D2 USP4
Entrez ID		1859	5933
HPRD ID		09018	00312
Ensembl ID		ENSG00000157540	ENSG00000080839
Uniprot IDs		A0A2R8Y6I6 Q13627	P28749
PDB IDs		2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK 6A1F 6A1G 6EIF 6EIJ 6EIL 6EIP 6EIQ 6EIR 6EIS 6EIV 6EJ4 6QU2 6S11 6S14 6S17 6S1B 6S1H 6S1I 6S1J 6T6A 6UIP 6UWY	1H28 4YOO 4YOS 4YOZ 5TUV
Enriched GO Terms of Interacting Partners?
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