DYRK1A and SF3B1

Data Source:
HPRD (in vitro, in vivo)

		DYRK1A	SF3B1
Description		dual specificity tyrosine phosphorylation regulated kinase 1A	splicing factor 3b subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Nuclear Speck Axon Dendrite Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U11/U12 SnRNP U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Self-association Tau Protein Binding Tau-protein Kinase Activity	RNA Binding MRNA Binding Protein Binding Splicing Factor Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Phosphorylation Nervous System Development Circadian Rhythm Viral Process Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Microtubule Polymerization Positive Regulation Of RNA Splicing Amyloid-beta Formation Peptidyl-serine Autophosphorylation Peptidyl-tyrosine Autophosphorylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Deacetylation	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Positive Regulation Of Gene Expression, Epigenetic
Pathways		G0 and Early G1	B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs		N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide Fostamatinib	H3B-8800
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) HIV-1 replication ( 21364930) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Neutrophil count ( 32888494) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Stroke ( 30383316) White blood cell count ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Major depressive disorder ( 27479909) Morning person ( 30696823) Schizophrenia ( 25056061 29483656 30285260) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		33 interacting genes: - AMPH APP CCNL2 CLASRP CREB1 CREBBP EIF2B5 FOXO1 GLI1 H2BC3 H3C1 H4C1 ID2 KPRP LATS2 LIN52 MAPT PEA15 PHYHIP PRKN RB1 RBL1 RNF169 SF3B1 SNCA SRSF1 SRSF4 SRSF5 TROAP YWHAB YWHAE YWHAG	100 interacting genes: APBB1 C11orf58 CALM1 CLK1 CSNK2A1 DUX4 DYRK1A ERG IL7R MELK MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC NUDT21 PHF5A PLRG1 PPP1R8 PRPF40A SF1 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 SUMO2 TCERG1 TOP1 U2AF2 WBP4
Entrez ID		1859	23451
HPRD ID		09018	09281
Ensembl ID		ENSG00000157540	ENSG00000115524
Uniprot IDs		A0A2R8Y6I6 Q13627	B4DGZ4 O75533
PDB IDs		2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK 6A1F 6A1G 6EIF 6EIJ 6EIL 6EIP 6EIQ 6EIR 6EIS 6EIV 6EJ4 6QU2 6S11 6S14 6S17 6S1B 6S1H 6S1I 6S1J 6T6A 6UIP 6UWY	2F9D 2F9J 2FHO 2PEH 3LQV 4OZ1 5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6N3E 6QX9 6Y50 6Y53 6Y5Q
Enriched GO Terms of Interacting Partners?
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