ABL2 and CAT

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)
HPRD (in vitro, in vivo)

		ABL2	CAT
Description		ABL proto-oncogene 2, non-receptor tyrosine kinase	catalase
Image
GO Annotations	Cellular Component	Cytosol Actin Cytoskeleton	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Peroxisome Peroxisomal Membrane Peroxisomal Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane Protein-containing Complex Secretory Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding	Peroxisome Targeting Sequence Binding Aminoacylase Activity Catalase Activity Antioxidant Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding
	Biological Process	Cellular Protein Modification Process Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Positive Regulation Of Oxidoreductase Activity Cellular Response To Retinoic Acid Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Protein Targeting To Peroxisome Triglyceride Metabolic Process Aging Cholesterol Metabolic Process Aerobic Respiration Response To Light Intensity UV Protection Response To Ozone Response To Lead Ion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Response To Inactivity Hemoglobin Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Insulin Response To Vitamin A Response To Vitamin E Response To L-ascorbic Acid Cellular Response To Oxidative Stress Response To Drug Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Response To Ethanol Response To Cadmium Ion Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Division Response To Hyperoxia Response To Fatty Acid Cellular Response To Growth Factor Stimulus Response To Phenylpropanoid Cellular Oxidant Detoxification
Pathways		Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling Negative regulation of FLT3	Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		ATP Dasatinib XL228 K-00546 Fostamatinib	Fomepizole Cannabidiol Medical Cannabis Nabiximols
Diseases			Acatalasia, including: Acatalasemia; Takahara's disease; Hypocatalasemia
GWAS		IgE grass sensitization ( 22036096)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		34 interacting genes: ABI2 ABL1 AR BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK KIT MAP3K10 MDM2 MET NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10 ZMAT1	8 interacting genes: ABL1 ABL2 APP EHHADH KEAP1 PTPN11 SUMO4 TLR10
Entrez ID		27	847
HPRD ID		01259	00282
Ensembl ID		ENSG00000143322	ENSG00000121691
Uniprot IDs		P42684	A0A384P5Q0 P04040
PDB IDs		2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5	1DGB 1DGF 1DGG 1DGH 1F4J 1QQW
Enriched GO Terms of Interacting Partners?
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