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DNMT1 and PCLAF
Data Source:
BioGRID
(unspecified method, affinity chromatography technology)
DNMT1
PCLAF
Description
DNA methyltransferase 1
PCNA clamp associated factor
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleus
Nucleoplasm
Centrosome
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
DNA (cytosine-5-)-methyltransferase Activity
Protein Binding
Zinc Ion Binding
DNA-methyltransferase Activity
Promoter-specific Chromatin Binding
Chromatin Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Methylation
Chromatin Organization
Ras Protein Signal Transduction
Maintenance Of DNA Methylation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K9 Methylation
C-5 Methylation Of Cytosine
Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
DNA Replication
Cellular Response To DNA Damage Stimulus
Centrosome Cycle
Response To UV
Translesion Synthesis
Regulation Of Cell Cycle
Pathways
PRC2 methylates histones and DNA
NoRC negatively regulates rRNA expression
SUMOylation of DNA methylation proteins
DNA methylation
Termination of translesion DNA synthesis
Drugs
Procaine
Azacitidine
Procainamide
Flucytosine
Decitabine
Palifosfamide
Epigallocatechin gallate
Diseases
GWAS
Birth weight (
31043758
)
Immature fraction of reticulocytes (
27863252
)
Narcolepsy (
24204295
)
Offspring birth weight (
31043758
)
Reticulocyte count (
27863252
)
Reticulocyte fraction of red cells (
27863252
)
Interacting Genes
41 interacting genes:
AKT1
BAZ2A
BRAP
CBX1
CSNK2B
DAXX
DCAF5
DMAP1
DNMT3A
DNMT3B
DYNLL1
E2F6
EED
EZH2
GSK3B
H3-4
H3C1
HDAC1
HDAC2
HELLS
HMGB1
L3MBTL3
LASP1
MECP2
NRIP1
PCLAF
PCNA
PRKAA2
RB1
RGS6
RPS6KA6
RUNX1
RUNX1T1
SETD7
SUMO2
SUV39H1
TRIM27
TSG101
UBB
UHRF1
YWHAQ
5 interacting genes:
DNMT1
FZR1
PCNA
TERF1
UHRF1
Entrez ID
1786
9768
HPRD ID
00532
13778
Ensembl ID
ENSG00000130816
ENSG00000166803
Uniprot IDs
I6L9H2
P26358
Q59FP7
Q15004
PDB IDs
3EPZ
3PTA
3SWR
4WXX
4YOC
4Z96
4Z97
5WVO
5YDR
6K3A
4D2G
6EHT
6GWS
6IIW
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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