DNMT1 and DCAF5

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		DNMT1	DCAF5
Description		DNA methyltransferase 1	DDB1 and CUL4 associated factor 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleoplasm Cytoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Zinc Ion Binding DNA-methyltransferase Activity Promoter-specific Chromatin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Ras Protein Signal Transduction Maintenance Of DNA Methylation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation C-5 Methylation Of Cytosine Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	Protein Ubiquitination Post-translational Protein Modification
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation	Neddylation
Drugs		Procaine Azacitidine Procainamide Flucytosine Decitabine Palifosfamide Epigallocatechin gallate
Diseases
GWAS		Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494 27863252) Neuroticism ( 29255261) Platelet count ( 32888494) Refractive error ( 32231278)
Interacting Genes		41 interacting genes: AKT1 BAZ2A BRAP CBX1 CSNK2B DAXX DCAF5 DMAP1 DNMT3A DNMT3B DYNLL1 E2F6 EED EZH2 GSK3B H3-4 H3C1 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 MECP2 NRIP1 PCLAF PCNA PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUMO2 SUV39H1 TRIM27 TSG101 UBB UHRF1 YWHAQ	1 interacting genes: DNMT1
Entrez ID		1786	8816
HPRD ID		00532	16032
Ensembl ID		ENSG00000130816	ENSG00000139990
Uniprot IDs		I6L9H2 P26358 Q59FP7	Q8TBB7 Q96JK2
PDB IDs		3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR 6K3A	3I89
Enriched GO Terms of Interacting Partners?
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