DYNC1H1 and PPP2R5C

Data Source:
BioGRID (biochemical)

		DYNC1H1	PPP2R5C
Description		dynein cytoplasmic 1 heavy chain 1	protein phosphatase 2 regulatory subunit B'gamma
Image
GO Annotations	Cellular Component	Extracellular Region Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Nucleoplasm Golgi Apparatus Cytosol
	Molecular Function	RNA Binding Protein Binding ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Neutrophil Degranulation Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Minus-end-directed Vesicle Transport Along Microtubule Regulation Of Metaphase Plate Congression Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly	Protein Dephosphorylation Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Protein Autophosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Protein Kinase B Signaling
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs			2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases		Distal hereditary motor neuropathies (dHMN)
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)	Anti-saccade response ( 29064472) Autism ( 20663923) Leukoderma in response to rhododendrol ( 32558222) Metabolite levels ( 23823483)
Interacting Genes		19 interacting genes: BRCA1 COX20 DISC1 DUX4 DYNLL1 EGFR KATNA1 KATNB1 LINC01554 MTNR1B NDEL1 PRKCD RHBDD2 SMAD2 SUMO2 TENT5A TNIK YWHAG YWHAQ	18 interacting genes: APP ATM AXIN1 BRCA1 CHEK2 EP300 IER3 MAPK1 MBP PAXIP1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1B PRKCD PXN SGO1
Entrez ID		1778	5527
HPRD ID		02524	03385
Ensembl ID		ENSG00000197102	ENSG00000078304
Uniprot IDs		Q14204	Q13362
PDB IDs		2BOR 2BOT 5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A	2IAE 2JAK 2NPP 2NYL 2NYM 3FGA 5JJA 5K6S 5SW9 5SWF 6OYL 6TOQ 6VOY 6VRO 6Z2Y
Enriched GO Terms of Interacting Partners?
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