DYNC1H1 and KATNB1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		DYNC1H1	KATNB1
Description		dynein cytoplasmic 1 heavy chain 1	katanin regulatory subunit B1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Cytosol Microtubule Plasma Membrane Katanin Complex Microtubule Cytoskeleton Membrane Growth Cone Midbody Neuronal Cell Body
	Molecular Function	RNA Binding Protein Binding ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Protein Binding Microtubule Binding Protein Heterodimerization Activity ATPase Regulator Activity Dynein Complex Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Neutrophil Degranulation Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Minus-end-directed Vesicle Transport Along Microtubule Regulation Of Metaphase Plate Congression Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly	Protein Targeting Microtubule Depolymerization Negative Regulation Of Microtubule Depolymerization Mitotic Chromosome Movement Towards Spindle Pole Positive Regulation Of Cell Death Positive Regulation Of Neuron Projection Development Positive Regulation Of Microtubule Depolymerization Regulation Of Catalytic Activity Microtubule Severing Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Distal hereditary motor neuropathies (dHMN)
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		19 interacting genes: BRCA1 COX20 DISC1 DUX4 DYNLL1 EGFR KATNA1 KATNB1 LINC01554 MTNR1B NDEL1 PRKCD RHBDD2 SMAD2 SUMO2 TENT5A TNIK YWHAG YWHAQ	6 interacting genes: DYNC1H1 KATNA1 PAFAH1B1 RXFP3 TGFBR1 XRN1
Entrez ID		1778	10300
HPRD ID		02524	04081
Ensembl ID		ENSG00000197102	ENSG00000140854
Uniprot IDs		Q14204	Q9BVA0
PDB IDs		2BOR 2BOT 5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A
Enriched GO Terms of Interacting Partners?
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