PPP2R5C and IER3

Data Source:
HPRD (in vitro)

		PPP2R5C	IER3
Description		protein phosphatase 2 regulatory subunit B'gamma	immediate early response 3
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Nucleoplasm Golgi Apparatus Cytosol	Nucleus Cytosol Integral Component Of Membrane
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	Protein Binding
	Biological Process	Protein Dephosphorylation Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Protein Autophosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Protein Kinase B Signaling	Apoptotic Process Anatomical Structure Morphogenesis Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Apoptotic Process Regulation Of Response To DNA Damage Stimulus
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS		Anti-saccade response ( 29064472) Autism ( 20663923) Leukoderma in response to rhododendrol ( 32558222) Metabolite levels ( 23823483)	Age-related macular degeneration ( 23455636) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Chronic obstructive pulmonary disease ( 30804561) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sleep duration ( 25469926) Small cell lung carcinoma ( 28604730) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476)
Interacting Genes		18 interacting genes: APP ATM AXIN1 BRCA1 CHEK2 EP300 IER3 MAPK1 MBP PAXIP1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1B PRKCD PXN SGO1	17 interacting genes: APP AQP2 CD79A CISD2 FHL2 FKBP7 GLP1R MAPK1 MAPK3 MDM2 PPP2R5B PPP2R5C PRNP SGTA SLC13A4 TMBIM6 TMX2
Entrez ID		5527	8870
HPRD ID		03385	04295
Ensembl ID		ENSG00000078304	ENSG00000137331
Uniprot IDs		Q13362	A0A1U9X7X2 P46695
PDB IDs		2IAE 2JAK 2NPP 2NYL 2NYM 3FGA 5JJA 5K6S 5SW9 5SWF 6OYL 6TOQ 6VOY 6VRO 6Z2Y
Enriched GO Terms of Interacting Partners?
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