DYNC1H1

Description		dynein cytoplasmic 1 heavy chain 1
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GO Annotations	Cellular Component	Extracellular Region Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm
	Molecular Function	RNA Binding Protein Binding ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Neutrophil Degranulation Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Minus-end-directed Vesicle Transport Along Microtubule Regulation Of Metaphase Plate Congression Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Distal hereditary motor neuropathies (dHMN)
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Novel Interacting Genes		9 novel interacting genes: ASB7 ATP2B3 ECSIT LMO4 MRE11 PPP2R5C PSMB9 SORBS2 ZBTB42
Interacting Genes		19 interacting genes: BRCA1 COX20 DISC1 DUX4 DYNLL1 EGFR KATNA1 KATNB1 LINC01554 MTNR1B NDEL1 PRKCD RHBDD2 SMAD2 SUMO2 TENT5A TNIK YWHAG YWHAQ
Entrez ID		1778
HPRD ID		02524
Ensembl ID		ENSG00000197102
Uniprot IDs		Q14204
PDB IDs		2BOR 2BOT 5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A
Enriched GO Terms of Interacting Partners?
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