SYNPO2 and FLNC

Data Source:
BioGRID (two hybrid, pull down)

		SYNPO2	FLNC
Description		synaptopodin 2	filamin C
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Nucleoplasm Cytosol Focal Adhesion Actin Cytoskeleton Z Disc Intracellular Membrane-bounded Organelle Vesicle Tethering Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere
	Molecular Function	Actin Binding Protein Binding Protein-macromolecule Adaptor Activity Filamin Binding Muscle Alpha-actinin Binding Alpha-actinin Binding 14-3-3 Protein Binding	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding
	Biological Process	Autophagosome Assembly Positive Regulation Of Actin Filament Bundle Assembly Chaperone-mediated Autophagy	Cell Junction Assembly Muscle Fiber Development
Pathways			Cell-extracellular matrix interactions
Drugs
Diseases			Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Diastolic blood pressure ( 30224653) Epithelial ovarian cancer ( 25581431) Estimated glomerular filtration rate after 5 years in renal transplantation (donor effect) ( 30920136) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) IgE levels in asthmatics ( 23967269)	Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		6 interacting genes: ACTN2 CDK6 FLNA FLNC YWHAG YWHAZ	35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		171024	2318
HPRD ID		15456	00018
Ensembl ID		ENSG00000172403	ENSG00000128591
Uniprot IDs		B4E258 Q9UMS6	Q14315 Q59H94
PDB IDs			1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX
Enriched GO Terms of Interacting Partners?
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