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SYNPO2 and ACTN2
Data Source:
BioGRID
(pull down)
SYNPO2
ACTN2
Description
synaptopodin 2
actinin alpha 2
Image
No pdb structure
GO Annotations
Cellular Component
Stress Fiber
Nucleus
Nucleoplasm
Cytosol
Focal Adhesion
Actin Cytoskeleton
Z Disc
Intracellular Membrane-bounded Organelle
Vesicle Tethering Complex
Extracellular Region
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Focal Adhesion
Z Disc
Filopodium
Cortical Actin Cytoskeleton
Platelet Alpha Granule Lumen
Pseudopodium
Dendritic Spine
Extracellular Exosome
Postsynaptic Density Membrane
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Molecular Function
Actin Binding
Protein Binding
Protein-macromolecule Adaptor Activity
Filamin Binding
Muscle Alpha-actinin Binding
Alpha-actinin Binding
14-3-3 Protein Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Cytoskeletal Protein Binding
Structural Constituent Of Muscle
Protein Domain Specific Binding
LIM Domain Binding
Nuclear Receptor Coactivator Activity
Titin Binding
Identical Protein Binding
Ion Channel Binding
Actin Filament Binding
FATZ Binding
Titin Z Domain Binding
Biological Process
Autophagosome Assembly
Positive Regulation Of Actin Filament Bundle Assembly
Chaperone-mediated Autophagy
MAPK Cascade
Platelet Degranulation
Cell Adhesion
Microspike Assembly
Muscle Filament Sliding
Regulation Of Membrane Potential
Regulation Of Apoptotic Process
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of Potassium Ion Transport
Sarcomere Organization
Positive Regulation Of Transcription, DNA-templated
Focal Adhesion Assembly
Actin Filament Uncapping
Cardiac Muscle Cell Development
Protein Localization To Plasma Membrane
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Positive Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Protein Localization To Cell Surface
Regulation Of NMDA Receptor Activity
Positive Regulation Of Endocytic Recycling
Positive Regulation Of Cation Channel Activity
Pathways
Platelet degranulation
Nephrin family interactions
Striated Muscle Contraction
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Diastolic blood pressure (
30224653
)
Epithelial ovarian cancer (
25581431
)
Estimated glomerular filtration rate after 5 years in renal transplantation (donor effect) (
30920136
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Heel bone mineral density (
30598549
)
IgE levels in asthmatics (
23967269
)
Metabolite levels (
23823483
)
Periodontitis (CDC/AAP) (
24024966
)
Interacting Genes
6 interacting genes:
ACTN2
CDK6
FLNA
FLNC
YWHAG
YWHAZ
104 interacting genes:
ACTN1
ACTN3
ADAM12
ADORA2A
AKTIP
ANG
ANGPTL7
ASH2L
ATP5MC1
ATXN2
ATXN7
BAD
BRMS1L
CAMK2A
CAMK2D
CAMK2G
CAPN1
CCDC187
CD27
CLEC4D
CNNM3
COIL
CRABP2
CRADD
DISC1
DLG1
DLG4
DUX1
DYNLT2B
EPS8L1
ERBIN
FAM50B
FBXL22
GATA3
GOLGA7
GRIN1
GRIN2B
GSTT1
H4C9
HSPB1
HTR1B
ITGB3BP
KAT2B
KATNAL2
KCNA4
KCNA5
KCNN2
LDB3
LRP12
LRRC7
MAST2
MED14
MICALL2
MOS
MRPL10
MYBPC2
MYOT
MYOZ1
MYOZ2
MYOZ3
MYPN
NCAPH2
NCOA2
NCOR1
NKAPD1
NOS3
NR1I2
NRIP1
NTAQ1
ODF3B
PALLD
PDLIM1
PDLIM3
PKD2
PPP1CB
PPP1R9B
PSMA1
QARS1
RACK1
RAVER1
RPL35
RPP14
RTP5
SAXO1
SELE
SNAI1
SNAPIN
SNW1
SP100
SPA17
SRP9
SSX2IP
ST7
SYNPO2
SYNPO2L
TNN
TOLLIP
TTN
TULP3
USP2
UTRN
ZC2HC1C
ZNF446
ZNRD2
Entrez ID
171024
88
HPRD ID
15456
00019
Ensembl ID
ENSG00000172403
ENSG00000077522
Uniprot IDs
B4E258
Q9UMS6
F6THM6
P35609
Q59FD9
PDB IDs
1H8B
1HCI
1QUU
4D1E
5A36
5A37
5A38
5A4B
6SWT
Enriched GO Terms of Interacting Partners
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