CFD and SERPINF2

Data Source:
HPRD (in vitro)

		CFD	SERPINF2
Description		complement factor D	serpin family F member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Platelet Degranulation Proteolysis Complement Activation Complement Activation, Alternative Pathway Notch Signaling Pathway Neutrophil Degranulation	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Platelet Degranulation Acute-phase Response Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Platelet degranulation Alternative complement activation Neutrophil degranulation	Platelet degranulation Dissolution of Fibrin Clot
Drugs		2-Aminobenzyl alcohol 3,4-Dichloroisocoumarin	Ocriplasmin Copper
Diseases		Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency	Alpha-2-plasmin inhibitor (a2-PI) deficiency
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494)	Blood protein levels ( 29875488) Calcium levels ( 24068962 20705733) Serum albumin level ( 23022100 29403010) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: HDHD2 SERPINF2	17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2
Entrez ID		1675	5345
HPRD ID		00600	02029
Ensembl ID		ENSG00000197766	ENSG00000167711
Uniprot IDs		A6XNE2 K7ERG9 P00746	P08697
PDB IDs		1BIO 1DFP 1DIC 1DST 1DSU 1FDP 1HFD 2XW9 2XWA 2XWB 4CBN 4CBO 4D9R 5FBE 5FBI 5FCK 5MT0 5MT4 5NAR 5NAT 5NAW 5NB6 5NB7 5NBA 5TCA 5TCC 6FTY 6FTZ 6FUG 6FUH 6FUI 6FUJ 6FUT 6QMR 6QMT
Enriched GO Terms of Interacting Partners?
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